Цитирование

[PLOS | ONE 2017] Meta-analysis of miRNA expression profiles for prostate cancer recurrence following radical prostatectomy -- "Network-based analysis was performed using a MIROB web tool (http://mirob.interactome.ru/) which has been designed to support analysis of microRNA expression data. MIROB (microRNA OncoBase) scans the set of input miRNAs to build any cancer pathways, detects key targets and Transcription Factors (TF) of candidate miRNAs, identifies any possible correlation between key targets and TF of candidate miRNAs and other diseases, and makes pathogenesis network.
...
MIROB tool was used to perform regulatory microRNA network analysis to identify regulators responsible for the observed patterns in miRNA meta-analysis studies.
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To understand the association of the DE microRNAs list with the most significant target genes and transcription factors, we conducted a regulatory gene network analysis using the MIROB web tool. CDKN1A and LASP1 were amongst the most significant target genes associated with the DE microRNAs.
"

[Placenta 2017] Dysregulated placental microRNAs in Early and Late onset Preeclampsia -- "RNA target prediction for selected miRNAs was performed with TargetScan v.7.0 [20], DIANA tools [[21], [22], [23]] and the miROB annotation web tool (http://mirob.interactome.ru/)."

[PLOS | one] Proteasome Functioning in Breast Cancer: Connection with Clinical-Pathological Factors. Elena E. Shashova, Yulia V. Lyupina, Svetlana A. Glushchenko, Elena M. Slonimskaya, Olga V. Savenkova, Alexey M. Kulikov
" Regulatory network between ERα and proteasome immune subunit LMP2 in breast cancer. MIR, microRNA; SOX4, PU.1 (SPI 1), MYC, transcription factors. Created within open informatics site MirOB"

[Uppsala: Acta Universitatis Upsaliensis, 2014] Small Intestinal Neuroendocrine Tumor Analyses. Somatostatin Analog Effects and MicroRNA Profiling. Su-Chen Li /UPPSALA UNIVERSITET
"MicroRNA OncoBase (MirOB) (www.mirob.interactome.ru/) software was used to identify biologically relevant gene networks and any potential miRNA target gene’s ontology information."

[Tumor Biology, jan 2015/springer] Over-expression of miR-10b in NPC patients: correlation with LMP1 and Twist1 -- "Supplementary Fig. S2: Regulatory network of miR-10b. This schematic representation is created within the open informatic’s site MirOB "

Targeted cancer therapy based on blocking the expression of genes and small doses of oxaliplatin. (file [.pdf])

[innoros.ru] Searching and analysis novel gene targets for colorectal cancer therapy by multiple comparison of clinical OMICs data and detail bioinformatics analysis, including network and pathway approaches, created by Stas Poyarkov and Russians leading bioinformatics team.

[researchgate.net] Does anyone have experience with Multi-Omics Interaction Network (GE + miRNA + Methylation + CNA)?

[.pdf] [Диссертация] "Профилирование экспрессии микроРНК в опухолях молочной железы и шеи. Сравнительный анализ". Веряскина Юлия Андреевна. (2016 год).
"Экспериментально доказанные гены-мишени миРНК и транскрипционные факторы. Массив данных сформирован при помощи базы данных mirOB (http://mirob.interactome.ru)."

[www.sys-med.de] Network analysis of HDAC-controlled microRNAs in neuroblastoma -- "Predicted protein-coding mRNA targets will be then systematically mapped to cellular pathways from the KEGG database and the mirOB database for cancer-specific pathways involving microRNAs among other database resources."

Медицинская Генетика, 2015 г., Том 14, №3 (153). Материалы VII Съезда Российского общества медицинских генетиков. -- "Анализ с помощью интерактивной базы для раково-специфичных генных сетей mirOB показал различные патогенетические пути, в которые вовлечены микроРНК разных групп. МикроРНК с положительными корреляциями связаны с процессами эпителиально-мезенхимального перехода (EMT), клеточным циклом и пролиферацией; смешанная группа связана с миграцией, инвазией и апоптозом."

Omictools MirOB profile

MirOB plugin in BioGPS


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Drugs and Targets there..
Oncosupressions microRNA chart there..
Oncogenic microRNA chart there..
graphviz test: